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Objective@#To discuss the application effect of Nursing-Mini-Clinical Evaluation Exercise (Nursing-Mini-CEX) based on the theory of extended skill circle to construct and implemented the clinical practice teaching scheme.@*Methods@#Applied convenient sampling in a hospital in Dalian and taked 42 grade 2012 undergraduates as control group, which will be given Nursing-Mini-CEX teaching model. 47 students of grade 2013 undergraduates as observation group, given on the Nursing-Mini-CEX teaching model based on extended skill circle theory, At the end of the clinical practice, we used the Nursing-Mini-CEX tools and the Teaching ability of Clinical Teaching Teachers questionnaire and the satisfaction scale of Nursing students' practice to evaluate the effect of the Nursing-Mini-CEX teaching model based on extended skill circle theory.@*Results@#The score of control group in Special care, nursing examination, nursing diagnosis, humanistic care, organizational effectiveness and overall evaluation were (6.26±1.01) 、(6.40±1.00) 、(6.37±1.11) 、(6.77±1.03) 、(6.37±1.17) 、(7.06±1.11) 、(6.89±1.11) , The experimental group students′ performance was higher than the control group in the Special care, nursing examination, nursing diagnosis, humanistic care, organizational effectiveness and overall evaluation, The scores were(7.10±1.14), (6.90±0.81), (7.19±0.86), (7.12±0.97), (7.43±0.91), (7.43±0.91), (7.43±0.80), with significant differences (t=1.523~3.640, P˂0.05) . The scores of clinical teachers′ teaching ability were higher than that of the control group (80.27 ± 13.90) ,the score was (86.68 ± 12.21) , With significant differences (t=3.83,P˂0.05) ,and the satisfaction degree of the experimental group was higher than that of the control group, With significant differences (t=0.827,P˂0.05) .@*Conclusion@#Nursing-Mini-CEX teaching model based on extended skill circle theory made the clinical teaching more systematic and standardized. It can improve clinical teaching quality and the nursing students′ clinical ablity, and it is well worth to apply in clinical.
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Objective To discuss the application effect of Nursing-Mini-Clinical Evaluation Exercise (Nursing-Mini-CEX) based on the theory of extended skill circle to construct and implemented the clinical practice teaching scheme. Methods Applied convenient sampling in a hospital in Dalian and taked 42 grade 2012 undergraduates as control group, which will be given Nursing-Mini-CEX teaching model. 47 students of grade 2013 undergraduates as observation group, given on the Nursing-Mini-CEX teaching model based on extended skill circle theory, At the end of the clinical practice, we used the Nursing-Mini-CEX tools and the Teaching ability of Clinical Teaching Teachers questionnaire and the satisfaction scale of Nursing students' practice to evaluate the effect of the Nursing-Mini-CEX teaching model based on extended skill circle theory. Results The score of control group in Special care, nursing examination, nursing diagnosis, humanistic care, organizational effectiveness and overall evaluation were(6.26±1.01)、(6.40±1.00)、(6.37±1.11)、(6.77±1.03)、(6.37±1.17)、(7.06±1.11)、(6.89 ± 1.11), The experimental group students′performance was higher than the control group in the Special care, nursing examination, nursing diagnosis, humanistic care, organizational effectiveness and overall evaluation , The scores were(7.10±1.14), (6.90±0.81), (7.19±0.86), (7.12±0.97), (7.43±0.91), (7.43± 0.91), (7.43±0.80), with significant differences(t=1.523~3.640, P?0.05). The scores of clinical teachers′teaching ability were higher than that of the control group(80.27±13.90),the score was(86.68±12.21), With significant differences(t=3.83,P?0.05),and the satisfaction degree of the experimental group was higher than that of the control group, With significant differences(t=0.827,P?0.05). Conclusion Nursing-Mini-CEX teaching model based on extended skill circle theory made the clinical teaching more systematic and standardized. It can improve clinical teaching quality and the nursing students′ clinical ablity, and it is well worth to apply in clinical.
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Objective To investigate the clinical application value of multi-directional liver acquisition with volume acceleration (LAVA)imaging in diagnosing adult intussusception.Methods Nine cases with adult intussusception confirmed by multi-directional LAVA imaging and operation were included in the study.The MRI manifestations were analyzed retrospectively.Results Of the 9 cases,there were 4 cases of small intestine intussusception,1 case of ileocecal intussusception,3 cases of ileocecum intussusception and 1 case of colon intussusception.MRI features showed"target"sign in 9 cases,"bowel within bowel"sign in 4 cases,"kidney-shaped"mass in 8 cases,double"target"sign in 3 cases,"8"character sign in 3 cases,mesenteric lymph node tumescence in 1 case and ileus in 1 case.Conclusion The multi-directional LAVA imaging can help to show the various features of intussusceptions.
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Objective To study the effect of artesunate on inflammatory responses to severe pneumonia by regulating macrophage migration inhibitory factor (MIF) in rats.Methods Total of 100 SD by random (random number) assigned,20 rats were control group,80 SD rats with severe pneumonia were caused by Klebsiella pneumoniae,60 SD rats were treated with different concentrations (20,40,80 mk/kg) of artesunate after modeling.The pathological changes of lung tissue,the level of MIF myeloperoxidase activity and inflammatory cell infiltration in lung tissue of rats were evaluated.Results After treatment with artesunate,the severity of inflammation was significantly alleviated in rats with severe pneumonia evidenced by decrease in myeloperoxidase activity [severe pneumonia:(17.5 ± 1.5) vs.treatment group:(7.5 ±2.0)] and reduction in inflammatory cell infiltration (severe pneumonia:27 × 106 vs.treatment group:12.5 × 106).Similarly,the artesunate also reduced the production of inflammatory cytokines significantly in bronchoalveolar lavage fluid (IL-1 in severe pneumonia group:(1 100 ± 50) pg/ml vs.treatment group:(400 ± 60) pg/ml;IL-6 in severe pneumonia group:(700-± 30) pg/ml vs.treatment group:(200 ±40) pg/ml;IL-10 in severe pneumonia group:(500 ± 70) pg/ml vs.treatment group:(200 ± 40) pg/ml;TNF-αin severe pneumonia group:(500 ± 80) pg/ml vs.treatment group:(150 ± 50) pg/ml.In addition,artesunate inhibited the level and production of MIF,thus inhibiting the inflammatory responses mediated by MIF.Conclusions Artesunate had a protective effect on pneumonia caused by Klebsiella pneumoniae in rats via inhibiting the inflammation responses mediated by MIF.This study provided a molecular basis for newly developed drugs applied to the treatment of pneumonia caused by Klebsiella pneumoniae in rats.
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Objective To investigate the correlation between serum procalcitonin (PCT) levels and infection sites,as well as between PCT and bacterial species in gram negative (G-) bacteria induced sepsis,so as to provide rationale for therapeutic strategy of using antibiotic in sepsis.Methods The data of patients with sepsis admitted in Emergency Department and ICU from January 2014 to June 2015 were retrospectively analyzed.The blood culture of G-bacteria and PCT detection were carried out simultaneously within 24 hours after admission.The clinical data was analyzed to find out the correlation between PCT levels and infection sites,as well as between PCT levels and pathogenic bacterial species.Results A total of 187 specimens (came from 162 patients) were enrolled in the study with a median age of 70 years old and a median sequential organ failure assessment (SOFA) score of 4.PCT levels were found to be associated with bacterial species.PCT level caused by Escherichia coli bacteremia infection was higher than that caused by Acinetobacter baumannii bacteremia and Burkholderia cepacia bacteremia infection (4.62 ng/mL vs.2.44 ng/mL;4.62 ng/mL vs.0.81 ng/mL;P ＜ 0.05).Receiver operating characteristic (ROC) analysis showed an area under the curve (AUC) for PCT was 0.61 to discriminate Escherichia coli infection from Acinetobacter baumannii infection and an AUC was 0.66 to discriminate Escherichia coli infection from Burkholderia cepacia infection.When the cutoff point of PCT was 30.32 ng/mL,it could predict Escherichia coli infection rather than Acinetobacter baumannii infection with 94.10％ specificity,90.00％ positive predictive value and positive likelihood ratio for 4.24.When the cutoff point of PCT was 8.01 ng/mL,it could predict Escherichia coli infection rather than Burkholderia cepacia infection with 85.70％ specificity,93.94％ positive predictive value,and positive likelihood ratio for 3.01.When PCT cutoff value reached 47.31 ng/mL,the specificity and positive predictive value were both 100.00％.PCT level caused by urinary tract infection was higher than that caused by pulmonary infection (11.58 ng/mL vs.2.07 ng/mL,P ＜ 0.05),and the AUC was 0.69.When the cutoff point of PCT was 32.11 ng/mL,it could predict Escherichia coli infection rather than Acinetobacter baumannii infection with 90.60％ specificity,86.18％ negative predictive value and positive likelihood ratio for 3.68.Conclusions PCT elevation in G-bacteria induced sepsis might be associated with infection sites and bacterial species.
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Objective To evaluate the diagnostic performances of bedside lung ultrasound (US) and chest radiography (CXR) in patients with severe pneumonia.Method Lung ultrasound (US),CXR and chest CT were performed in sequence in adult patients admitted to the emergency department for suspected acute respiratory failure caused by severe pneumonia.Here,chest CT served as a golded standard for comparison.The diagnostic efficacy of US for the detection of severe pneumonia,defined as rapidity and accuracy (sensitivity,specificity,positive predictive value,negative predictive value) were compared with CXR.Results The number of patients with consolidation of lung,pleural alteration,subpleural pathological changes,and pleural effusion in the severe pneumonia group was higher than that in the nonpneumonia group.Sensitivity of bedside ultrasound examination for the diagnosis of severe pneumonia was 95.7％,and specificity 96.3％,positive predictive value 95.7％,negative predictive value 96.3％,and accuracy 96.0％.There were differences in sensitivity,negative predictive value and accuracy found between CXR and US.Conclusions Bedside chest ultrasound is a reliable device for the diagnosis of severe pneumonia,and superior to CXR in this setting,allowing a more prompt diagnosis and treatment.
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<p><b>OBJECTIVE</b>To observe the effects of oral administration of guanxin II decoction (GX II) on cardiovascular function, especially on the dynamics of coronary blood flow in healthy males.</p><p><b>METHODS</b>Changes of heart rate, diastolic pressure, systolic pressure, left ventricular ejection fraction (LVEF), E peak, A peak, E/A value of mitral flow, diastolic peak velocity (Vmax) and diastolic flow velocity time integrals (VTI) of left anterior descending coronary artery (LAD) in 11 healthy male subjects were measured before and after oral administration of GX II, using non-invasive echocardiogram.</p><p><b>RESULTS</b>Compared with those before GX II administration, the changes after administration in heart rate, systolic pressure, diastolic pressure, LVEF, E peak, A peak and E/A value, were insignificantly different (P>0.05), but the Vmax and VTI significantly increased at 30 min, 60 min, 90 min and 120 min after GX II administration (P<0.05).</p><p><b>CONCLUSION</b>To increase the coronary blood flow is possibly one of the mechanisms of GX II in treating coronary heart disease and angina pectoris.</p>
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Adolescent , Adult , Humans , Male , Middle Aged , Blood Flow Velocity , Coronary Circulation , Coronary Disease , Drug Therapy , Coronary Vessels , Diastole , Drugs, Chinese Herbal , Pharmacology , Echocardiography , Heart Rate , Systole , Vasodilator Agents , Pharmacology , Ventricular Function, LeftABSTRACT
Objective To compare the antineoplastic immunological effects of nanoemulsion-encapsulated MAGE1-HSP70 and SEA(the ratio of MAGE1-HSP70 fusion protein to SEA superantigen was 100∶1)as NE(MHS)vaccine as given in different routes,and try to look for a novel and effective immune route.Methods NE(MHS)was prepared using magnetic ultrasound methods,and the size,the encapsulation rate and the stability of the nanoemulsion vaccine were evaluated.C57BL/6 mice were immunized via p.o.,subcut.,i.v.,or i.p.route.The cellular immunocompetence was detected by ELISpot assay and LDH release assay.The therapeutic and tumor challenge assay were examined too.Results When the vaccine was given orally,the tumor masses formed 28 days after B16-MAGE1 inoculation in mice were markedly bigger than that formed in the mice of the other groups(P